With em /em -tryptase monomers formed with B12 anti-tryptase Fab (23), C3 and C4 are cleaved to create the corresponding anaphylatoxins efficiently, that are gradually degraded after that

While nuclear factor-kappa B (NF-B) and hypoxia-inducible factor 1-alpha (HIF-1) play important roles in the growth and survival of hematopoietic malignancies13C15, VC inhibits the survival and growth of K562 leukemic cells via the downregulation of HIF-1 transcription by inhibiting NF-B activation and suppressing the expression of HIF-1-regulated antiapoptotic proteins of the Bcl-2 family, including myeloid leukemia cell differentiation protein (Mcl-1), B-cell lymphoma (Bcl)-xL, and Bcl-212